8/5/2023 0 Comments Cord blood definition![]() ![]() Moreover, umbilical cord blood contains at least three types of stem cells including a population of hematopoietic stem cells (HSCs) and a population of Mesenchymal stem cells (MSCs), which are a multipotent stem cells highly similar to Mesenchymal stem cells (MSCs) of the bone marrow. This mixture includes hematopoietic cells including erythrocytes and leukocytes. Umbilical cord blood contains a highly heterogeneous mixture of cells. Nevertheless, advances in the production of different tissue groups from umbilical cord blood stem cells, from the three germ layers, has highlighted the additional potential of umbilical cord blood in treatment of other pathological disorders and medical applications including regenerative medicine and tissue engineering. Umbilical cord blood use was then restricted to blood-proliferation-based diseases. In later years, it was used regularly for transplantation in hematology for bone marrow replacement, following either hematological malignancy or bone marrow failure after chemotherapy. Beside its role in development, umbilical cord blood has been also involved in therapeutic applications, which was reported for the first time in 1972 by clinicians in the United States to treat a case with lymphoblastic leukemia. The umbilical cord blood is regarded as the “life line” that supplies the developing fetus with the important nutrition elements and oxygen required for proper fetal development. We also discuss the potential use of umbilical cord blood stem cells as a therapeutic tool for several diseases and disorders in light of ongoing clinical trials. Hence, in this review we provide simple and direct descriptions of different populations of stem cells in umbilical cord blood in an attempt to clarify the confusion caused by the existence of multiple names given to certain cord blood stem cells. ![]() Besides the confusion caused by the introduction of these different names, some of the terms used by different groups are inaccurate and misleading when considering the molecular and cellular properties of such cells. Due to the absence of standardized criteria for characterizing and naming cord blood stem cells, different terms and acronyms have been introduced to describe certain cell populations. It has been shown that this blood contains at least three populations of stem cells, each with unique features and properties. ![]() Umbilical cord blood is the blood found in the vessels of the umbilical cord and placenta. Keywords: Umbilical Cord Blood Stem Cell Embryonic Stem Cell Adult Stem Cell Cell Therapy *Corresponding Author: 27 October 2011 revised 31 November 2011 accepted 12 December 2011 Department of Pathology, Human Genetics Unit, Faculty of Medicine, Kuwait University, Kuwait, The State of Kuwait ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |